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Schematic representation of thrombin-triggered activation of perfluorobutane-filled (PFB-filled) ACPP-labeled microbubbles (ACPP-MBs). After ACPP cleavage, the ACPP-MB surface becomes positively charged and adheres to the negatively charged surfaces, such as those of red blood cells, fibrin, and platelets. Adapted from Servier Medical Art.
