Table 1.
Results of the Bayesian analysis of the evolutionary history of variola virus (VARV).
| Data Set and Model | Substitution Rate (×10−6 subs/site/year) | tMRCA VARV |
|---|---|---|
| 1 Strict clock—45 genomes | 5.44 (4.73–6.16) |
1514 (1554–1645) |
| Relaxed clock—45 genomes | 5.89 (4.19–7.67) |
1515 (1366–1642) |
| 2 Strict clock—43 genomes | 8.27 (7.48–9.10) |
1620 (1598–1642) |
| Relaxed clock—43 genomes | 8.73 (7.02–10.02) |
1619 (1566–1654) |
1 Based on the 45 VARV genome data used by Pajer et al. [1] including V1588 and V563. 2 Based on 43 VARV genomes excluding V1588 and V563 for which a prior distribution is given on their age. Strict = strict molecular clock; Relaxed = relaxed (uncorrelated lognormal) molecular clock.