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. 2017 Oct 20;9(10):305. doi: 10.3390/v9100305

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© 2017 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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CNP058:Bim BH3 complex interface. Surface representation of (A) CNP058:Bim BH3 domain complex, (B) FPV039:Bik BH3 domain complex, and (C) Mcl-1:Bim BH3 domain complex. The view is into the conserved hydrophobic ligand binding groove formed by α-helices 2–5. The surfaces are shown in grey. Residues involved in interactions are shown as sticks and labeled. Hydrogen bonds and ionic interactions between CNP058 and Bim are denoted as black dotted lines. PDB ID: FPV039:Bik = 5TZP, Mcl-1:Bim = 2NL9.