Effects of aqueous Cynanchum wilfordii extract (CWW) on prostate hyperplasia. Histological examination of prostate tissues was performed 24 h after the final testosterone injection. Prostate tissues were fixed, sectioned at 4-μm thickness, and stained with hematoxylin and eosin (H&E; magnification, ×10; small box, ×20). BPH: benign prostatic hyperplasia; (a) Sham/vehicle: sham-operated and phosphate-buffered saline (PBS), oral (p.o.); (b) BPH/vehicle: testosterone, subcutaneous (s.c.) and PBS, p.o.; (c) BPH/finasteride: testosterone: s.c. and finasteride 5 mg/kg, p.o.; (d) BPH/CWW 50: testosterone, s.c. and CWW 50 mg/kg, p.o.; (e) BPH/CWW 100: testosterone, s.c. and CWW 100 mg/kg, p.o.; (f) BPH/CWW 200: testosterone, s.c. and CWW 200 mg/kg, p.o.