Table 4.
Current clinical trials on anthocyanins as potential therapy against insulin resistance and/or diabetes/obesity.
| Clinical Trial Identifier No. | Objective | Voluntary and Dose | Status |
|---|---|---|---|
| NCT01245270 | Single supplement of standardized bilberry extract (36% w/w anthocyanins) modifies glycemic response in persons with type-2 diabetes controlled by diet and lifestyle | 8 male patients of age between 40 and 70 years with type-2 diabetes given a single oral capsule of 0.47 g standardized blueberry extract followed by a polysaccharide drink in a double blind cross over intervention | Completed |
| NCT01005420 | The effect of anthocyanins in the form of blueberry powder on enhancing insulin sensitivity in insulin resistant and obese human | 37 male and female of age 20 years and older taking 45 g of blueberry powder per day as a smoothie | Completed |
| NCT02689765 | Effect of purified anthocyanins from bilberries and black currant on insulin resistance, glucose and lipid metabolism disorders | 160 humans both male and female with type-2 diabetes of age 40–75 years taking two 80 mg anthocyanin capsule twice a day for 24 weeks | Completed |
| NCT 01883401 | Investigate the effect of low and high doses of freeze-dried strawberries in cardiovascular risk factor in subjects with abnormal adiposity and dyslipidemia | 60 male and female patients of age between 19 and 72 years were given 25 and 50 g of dried strawberries | Completed |
| NCT 02340039 | The acute effect of black currant and apple extract on postprandial glycemia | 34 male and female patients of age between 20 and 60 years were given 600 mg of black current anthocyanins and 600 mg of apple polyphenols | Completed |
| NCT 02650726 | Effect of purified anthocyanins on high density lipoprotein and endothelial function in subjects with type-2 diabetes | 80 male and female patients of age between 40 and 60 years were given daily dose of 320 mg anthocyanin for 24 weeks in a randomized double blinded placebo-controlled trial | Completed |
| NCT 01053793 | A trial to measure the glycemic index and polyphenol bioavailability of four different varieties of potato | 10 male and female patients of age between 18 and 50 years were given 50 g of cooked purple, red, yellow and white potatoes | Completed |
| NCT 02317211 | Effect of purified anthocyanins on oxidative stress and glycemic control in subjects with type-2 diabetes | 70 patients of age between 25 and 65 years were given 320 mg anthocyanin daily for 12 weeks in a randomized double blinded placebo-controlled trial | Completed |
| NCT 01720511 | Pilot study of the effect of purple rice on glucose tolerance, serum lipid and inflammation | 10 male and female patients of age 18 years and above were given one cup of rice into their dishes and consumed at lunch and dinner each day for 4 weeks (equivalent to 4 ounces of uncooked rice/day) | Completed |
| NCT O2035592 | Dose dependent impact of blueberry powder intake on insulin sensitivity and resistance | 144 male and female of age 50–74 years | Active |
| NCT 02291250 | Effect of black currant containing anthocyanins on glucose metabolism | 16 obese male female of 21–70 age | Recruiting |
| NCT02972996 | Effect of blueberry consumption on cardiometabolic prevention in type-2 diabetes patients | 48 male patients of age between 45 and 75 years were given 22 g of blueberry powder in a randomized experiment | Recruiting |
| NCT 03213288 | The effect of bilberry fruit and black rice derived anthocyanins on lipid status in adults | 50 male and female patients of age 45 years and older were given 320 mg of anthocyanins for 28 days | Recruiting |
| NCT 02940080 | Effect of anthocyanins extracted from purple potatoes on healthy study subjects Postprandial glycaemia and insulinemia | 20 male patients of age between 18 and 45 years were given 168 mg of anthocyanins extracted from purple-flashed potatoes added to steam-cooked mashed potatoes in water | Recruiting |
| NCT 02291250 | Effect of soft fruit on postprandial blood glucose | 16 overweight male and female patients of age between 21 and 70 years were given black current (200 g) and green currant (200 g) | Recruiting |
| NCT01180712 | Study of oral anthocyanins on insulin resistance | 60 obese type-2 diabetic males of age 40–70 years taking 1.4 g of concentrate blueberry extract in a hard gelatin capsule administered thrice a day for 21 days | Recruiting |
(NCT numbers refer to the source of www.clinicalTrails.gov).