Table 2.

Estimation of multiple supplementation effects on preeclampsia.

Intervention	Calcium	Vitamin D	Calcium + Vitamin D
Calcium	0.49 (0.35 0.69) * {66.1, 31.6}	0.89 (0.33, 2.41) *†	1.18 (0.58, 2.37) *‡
Vitamin D		0.43 (0.17, 1.11) † {70.7, 47.4}	1.33 (0.42, 4.18) †‡
Calcium + Vitamin D			0.57 (0.30, 1.10) ‡ {52.2, 19.6}

Values are expressed as pooled RR along with 95% CIs in round parentheses; on diagonal cells comparing supplement vs. placebo, off the diagonal cells comparing column vs. row supplements; values < 1 indicates that the intervention listed in the column is more effective than the one in the row; Values in the diagonal in curly parentheses indicate surface under the cumulative ranking curve and the probability of being the best treatment. The larger is the surface under the cumulative ranking curve or probability of being the best treatment, the better is the treatment. * Calcium vs. Placebo: 16 RCTs, n = 12,876 vs. 13,060, number of PE cases = 722 vs. 931; ^† Vitamin D vs. Placebo: 3 RCTs, n = 203 vs. 154, number of PE cases = 20 vs. 14; ^‡ Calcium + Vitamin D vs. Placebo: 4 RCTs, n = 584 vs. 585, number of PE cases = 27 vs. 55; *^‡ Calcium + Vitamin D vs. Calcium: 1 RCT, n = 89 vs. 86, number of PE cases = 10 vs. 6; *^† Calcium vs. Vitamin D: 19 RCTs, n = 25,936 vs. 357, number of PE cases = 722 vs. 14; ^†‡ Calcium + Vitamin D vs. Vitamin D: 7 RCTs, n = 1169 vs. 357, number of PE cases = 55 vs. 14.