Figure 6.

Schematic diagram summarizes diabetes-induced oxidative stress that leads to diabetic retinopathy. The findings of the current study showing that diabetes-induced oxidative stress activates apoptosis and decreases neurotrophic support leading to neuronal damage. Treatments with naringenin that target diabetes, oxidative stress and neurodegenerataive factors might be effective therapeutics in attenuating retinal neurodegeneration in diabetic retinopathy. Bcl-2; B cell lymphoma 2. Bax; Bcl-2 associated X protein. TrkB; Tropomyosin receptor kinase. BDNF; brain derived neurotrophic factor.