Table 5.
SVR12 values for observational study regimens with and without RBV in patients who were (i) cirrhotic or non-cirrhotic a, (ii) treatment-experienced or -naïve, or (iii) HIV-positive or -negative
| Regimen | SVR12% [95% CI] | ||||||
|---|---|---|---|---|---|---|---|
| Cirrhotic | Non-cirrhotic | Treatment-experienced | Treatment-naïve | HIV-positive | HIV-negative | ||
| DCV + SOF containing regimens | |||||||
| DCV + SOF | +RBV | 77.3 [70.9, 83.2] n = 186 |
83.3 [41.4, 100.0] n = 6 |
74.4 [66.7, 81.6] n = 139 |
100.0 [86.1, 100.0] n = 12 |
100.0 [73.9, 100.0] n = 6 |
NR |
| −RBV | 85.4 [79.7, 90.3] n = 215 |
98.1 [92.2, 100.0] n = 54 |
81.1 [65.3, 93.5] n = 35 |
90.5 [73.4, 99.8] n = 21 |
97.7 [82.5, 100.0] n = 20 |
NR | |
| ±RBV | 84.8 [33.3, 100.0]b n = 5 |
NR | 100.0 [73.2, 100.0]b n = 6 |
NR | NR | 90.9 [65.0, 100.0]b n = 11 |
|
| LDV containing regimens | |||||||
| LDV + SOF | +RBV | 64.9 [52.0, 76.8] n = 57 |
NR | 70.9 [54.0, 86.0] n = 63 |
NR | NR | NR |
| −RBV | 40.0 [1.8, 86.2] n = 5 |
NR | 28.6 [1.0, 68.2] n = 7 |
NR | NR | NR | |
| SOF containing regimens | |||||||
| SOF | +RBV | 49.3 [40.8, 57.7] n = 144 |
81.9 [74.7, 88.2] n = 138 |
60.5 [50.2, 70.4] n = 105 |
74.3 [66.4, 81.5] n = 144 |
100.0 [30.3, 100.0] n = 2 |
NR |
| −RBV | NR | NR | NR | NR | NR | NR | |
| SOF ± Peg-IFN | +RBV | 90.9 [74.5, 99.8] n = 22 |
NR | 91.7 [67.6, 100.0] n = 12 |
NR | NR | NR |
| −RBV | NR | NR | NR | NR | NR | NR | |
| Peg-IFN containing regimens | |||||||
| Peg-IFN | +RBV | 63.9 [60.0, 67.7] n = 713 |
77.8 [74.8, 80.7] n = 845 |
49.4 [43.1, 55.7] n = 257 |
63.3 [62.6, 64.1] n = 16,031 |
66.4 [63.1, 69.6] n = 874 |
63.7 [62.8, 64.6] n = 11,995 |
| −RBV | NR | NR | NR | NR | NR | NR | |
| Peg-IFN + SOF | +RBV | 100.0 [30.3, 100.0] n = 2 |
NR | NR | NR | NR | NR |
| −RBV | NR | NR | NR | NR | NR | NR | |
DCV daclatasvir, IFN interferon, LDV ledipasvir, NR not reported, RBV ribavirin, r ritonavir, SOF sofosbuvir, SVR12 sustained virological response at 12 weeks
aIn this analysis, cohorts were considered non-cirrhotic if 0% of patients were cirrhotic
bData from study(s) in which stratification by RBV use was not recorded