Table 1.
Description | Method | Limitations |
---|---|---|
Key considerations | Key considerations | Key considerations |
1. Report the number of individuals with missing data for each variable in the reported analysis by treatment group | 1. Identify a plausible missingness assumption for the specific patterns and setting analysed | 1. Acknowledge and quantify the impact of the missing data on the results |
2. Describe the missing data patterns for all variables included in the economic analysis (is missingness on one variable associated with missingness on another variable? Is there a longitudinal aspect to the data?) | 2. State the method and software used in the base-case analysis | 2. State possible weaknesses and issues with respect to the method and assumptions |
3. Discuss plausible reasons why values are missing (e.g. death) | 3. For more general methods, provide details about their implementation | |
4. Perform a plausible robustness analysis; provide and discuss the results | ||
Optimal considerations | Optimal considerations | |
1. Provide supplementary material about the preliminary analysis on missingness (e.g. descriptive plots and tables) | 1. Provide supplementary material about the method implementation in the base-case and robustness analysis (e.g. software implementation code) |
aFor example, in multiple imputation, state the imputation model specification and variables included, the number of imputations, post imputation checks