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. 2017 Nov 17;13:1744806917743479. doi: 10.1177/1744806917743479

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — PolyMorphine blocks SNI-induced hypersensitivity longer than free morphine. SNI mice treated with 200 mg/kg of PolyMorphine (n = 8) show reduced hypersensitivity compared to control SNI mice (n = 8) for up to 24 h after administration. SNI mice treated with 10 mg/kg of free morphine (n = 8) show reduced hypersensitivity compared to control SNI mice for only 2 h after administration. Two-way ANOVA, overall main effect of treatment, *P = 0.0153; overall main effect of time, ***P < 0.0001; Bonferroni post hoc tests compared to vehicle (saline), *P < 0.05 and ***P < 0.0001. SNI: spared nerve injury.