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. 2017 Nov 17;13:1744806917743479. doi: 10.1177/1744806917743479

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 5. — PolyMorphine and free morphine induce constipation and hyperactivity. (a) Mice treated with 200 mg/kg of PolyMorphine (n = 6) or 10 mg/kg of free morphine (n = 8) show constipation effects at 3-h post-injection compared to control animals (n = 6), with no effects one to three days post-injection. (b) Mice treated with 200 mg/kg of PolyMorphine (n = 6) show hyperactivity at one-day post-injection with no effects 3-h or two to three days post-injection compared to vehicle-treated animals (n = 6). Mice treated with 10 mg/kg of free morphine (n = 8) show hyperactivity at 3-h post-injection with no effects one to three days post-injection compared to vehicle-treated animals. Constipation—two-way ANOVA, overall main effect of treatment *P = 0.0385, overall main effect of time, ***P < 0.0001; Bonferroni post hoc tests compared to vehicle, **P < 0.01. Hyperactivity—two-way ANOVA, overall main effect of treatment, P = 0.1275; overall main effect of time, ***P < 0.0001; Bonferroni post hoc tests compared to vehicle, *P < 0.05 and ***P < 0.0001.