Fig. 1.

Conservation analysis of fluorothreonine-associated proteins. A total of four gene clusters for fluorothreonine (X = F) biosynthesis were found within sequenced organisms. Organofluorine loci were identified by the presence of a fluorothreonine transaldolase CDS (black) and all were found to contain homologs of both the INS superfamily protein FthB (red) and the EamA-like protein FthC (blue). In addition, the biosynthetically unrelated chlorothreonine (X = Cl) gene cluster also contains similar organization with respect to these two functions.