Table 4.

Quantification of the magnitude of drug effects. Mean and standard error on the mean (SE) are shown for each session. At 1 h, 3 h and 5 h, the values quoted are changes from the pre-tiagabine session. The significance of these pairwise changes is indicated by * p < 0.05 and **p < 0.0001.

Parameter	Mean (SE) before tiagabine administration	Mean (SE) change at 1-hr post tiagabine	Mean (SE) change at 3-hr post tiagabine	Mean (SE) change at 5-hr post tiagabine
Peak Alpha Frequency/Hz	11.0 (0.4)	−0.7 (0.3)*	−1.7 (0.3)**	−1.6 (0.3)**
Peak Beta Frequency/Hz	17.3 (0.4)	−0.6 (0.3)	−1.0 (0.4)*	−1.0 (0.4)*
Peak Gamma Frequency/Hz	53.4 (1.7)	−4.0 (1.5)*	−5.9 (0.8)**	−4.3 (1.2)*
G8, excitatory connection from layer 4 stellates to layer 2 superficial pyramidals	2.8 (0.2)	−0.2 (0.1)*	−0.1 (0.1)	−0.1 (0.2)
T3, inhibitory interneuron decay constant/ms	3.1 (0.1)	0.2 (0.1)*	0.3 (0.1)*	0.3 (0.1)*