Key resource table.

Reagent type (species) or resource	Designation	Source or reference	Identifiers	Additional information
Transgenic mice (mus musculus), both sexes	Rhodopsin-Pro23His	The Jackson Laboratory	Jackson Stock No: 017628; RRID:IMSR_JAX:017628
Transgenic mice (mus musculus), both sexes	Nr2e3-Rd7	The Jackson Laboratory	Jackson Stock No: 004643; RRID:IMSR_JAX:004643
C57Bl6J mice (mus musculus), both sexes	Wild type	The Jackson Laboratory	Jackson Stock No: 000664; RRID:IMSR_JAX:000664
Chemical compound	Photoregulin3 (PR3)	ChemDiv, and then synthesized in Ding Lab	PubChem CID: 2092851
Chemical compound	Photoregulin1 (PR1)	ChemDiv, and then synthesized in Ding Lab	PubChem CID: 7901316
Antibody	Anti- Rhodopsin (Rho4D2), mouse monoclonal	Dr. Robert Molday, UBC	RRID:AB_2315273	1:250
Antibody	Anti-S Opsin, goat polyclonal	SCBT	Sc-14363; RRID:AB_2158332	1:400
Antibody	Anti Cone Arrestin, rabbit polyclonal	Millipore	AB15282; RRID:AB_1163387	1:1000
Antibody	Anti-Otx2, goat polyclonal	R&D Systems	AF1979; RRID:AB_2157172	1:200
Antibody	Anti-Nr2e3, mouse monoclonal	R&D Sysems:	PP-H7223-00; RRID:AB_2155481	1:10,000
Antibody	Anti-Nrl, rabbit polyclonal	Chemicon	Ab5693	1:10,000
Antibody	Anti-beta actin, mouse monoclonal	Abcam	Ab6276; RRID:AB_2223210	1:20,000
Recombinant DNA	HsCD00084154 (Nr2e3)	DNASU	HsCD00084154
Recombinant DNA	BR-225Luc	Dr. Shiming Chen, Washington University; PMID: 15689355
Recombinant DNA	S Opsin 600 pGL3	Dr. Douglas Forrest, NIH; PMID: 16574740
Recombinant DNA	pRL-CMV	Promega	E6931
Recombinant DNA	hNRL-pCMVSport6	Open Biosystems	MHS1010-58005
Recombinant DNA	hCRX-pCMVSport6	Open Biosystems	MHS1010-73672
Recombinant DNA	hNR2E3-pcDNA3.1/HisC	Dr. Shiming Chen, Washington University; PMID: 15689355
Recombinant DNA	HsCD00329674 (RORB)	DNASU	HsCD00329674