Table 12.
Five-Year Total, Annual Average Totala, and Annual Average Age-Adjusted Incidence Ratesb for Brain and Other Central Nervous System Tumors in Children and Adolescents (Age 0-19 Years), by Major Histology Grouping, Histology, and Sex, CBTRUS Statistical Report: NPCR and SEER, 2010-2014
| Histology | Total | Male | Female | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Five-Year Total | Annual Average | Rate | 95% CI | Five-Year Total | Annual Average | Rate | 95% CI | Five-Year Total | Annual Average | Rate | 95% CI | |
| Tumors of Neuroepithelial Tissue | 15,556 | 3,111 | 3.78 | 3.72-3.84 | 8,367 | 1,673 | 3.98 | 3.89-4.06 | 7,189 | 1,438 | 3.57 | 3.49-3.65 |
| Pilocytic astrocytoma | 3,751 | 750 | 0.91 | 0.88-0.94 | 1,926 | 385 | 0.92 | 0.88-0.96 | 1,825 | 365 | 0.91 | 0.87-0.95 |
| Diffuse astrocytoma | 1,062 | 212 | 0.26 | 0.24-0.27 | 565 | 113 | 0.27 | 0.25-0.29 | 497 | 99 | 0.25 | 0.23-0.27 |
| Anaplastic astrocytoma | 409 | 82 | 0.10 | 0.09-0.11 | 216 | 43 | 0.10 | 0.09-0.12 | 193 | 39 | 0.10 | 0.08-0.11 |
| Unique astrocytoma variants | 468 | 94 | 0.11 | 0.10-0.12 | 269 | 54 | 0.13 | 0.11-0.14 | 199 | 40 | 0.10 | 0.09-0.11 |
| Malignant | 218 | 44 | 0.05 | 0.05-0.06 | 128 | 26 | 0.06 | 0.05-0.07 | 90 | 18 | 0.04 | 0.04-0.05 |
| Non-Malignant | 250 | 50 | 0.06 | 0.05-0.07 | 141 | 28 | 0.07 | 0.06-0.08 | 109 | 22 | 0.05 | 0.04-0.07 |
| Glioblastoma | 721 | 144 | 0.17 | 0.16-0.19 | 392 | 78 | 0.19 | 0.17-0.20 | 329 | 66 | 0.16 | 0.15-0.18 |
| Oligodendroglioma | 199 | 40 | 0.05 | 0.04-0.06 | 100 | 20 | 0.05 | 0.04-0.06 | 99 | 20 | 0.05 | 0.04-0.06 |
| Anaplastic oligodendroglioma | 29 | 6 | 0.01 | 0.00-0.01 | -- | -- | -- | -- | 16 | 3 | 0.01 | 0.00-0.01 |
| Oligoastrocytic tumors | 123 | 25 | 0.03 | 0.02-0.04 | 61 | 12 | 0.03 | 0.02-0.04 | 62 | 12 | 0.03 | 0.02-0.04 |
| Ependymal tumors | 1,226 | 245 | 0.30 | 0.28-0.31 | 681 | 136 | 0.32 | 0.30-0.35 | 545 | 109 | 0.27 | 0.25-0.29 |
| Malignant | 1,023 | 205 | 0.25 | 0.23-0.26 | 571 | 114 | 0.27 | 0.25-0.29 | 452 | 90 | 0.22 | 0.20-0.25 |
| Non-Malignant | 203 | 41 | 0.05 | 0.04-0.06 | 110 | 22 | 0.05 | 0.04-0.06 | 93 | 19 | 0.05 | 0.04-0.06 |
| Glioma malignant, NOS | 2,724 | 545 | 0.66 | 0.64-0.69 | 1,371 | 274 | 0.65 | 0.62-0.69 | 1,353 | 271 | 0.67 | 0.64-0.71 |
| Choroid plexus tumors | 403 | 81 | 0.10 | 0.09-0.11 | 228 | 46 | 0.11 | 0.09-0.12 | 175 | 35 | 0.09 | 0.07-0.10 |
| Malignant | 102 | 20 | 0.02 | 0.02-0.03 | 52 | 10 | 0.02 | 0.02-0.03 | 50 | 10 | 0.02 | 0.02-0.03 |
| Non-Malignant | 301 | 60 | 0.07 | 0.06-0.08 | 176 | 35 | 0.08 | 0.07-0.10 | 125 | 25 | 0.06 | 0.05-0.07 |
| Other neuroepithelial tumors | 30 | 6 | 0.01 | 0.00-0.01 | -- | -- | -- | -- | 25 | 5 | 0.01 | 0.01-0.02 |
| Malignant | 25 | 5 | 0.01 | 0.00-0.01 | -- | -- | -- | -- | 22 | 4 | 0.01 | 0.01-0.02 |
| Non-Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Neuronal and mixed neuronal-glial tumors | 1,687 | 337 | 0.41 | 0.39-0.43 | 932 | 186 | 0.44 | 0.41-0.47 | 755 | 151 | 0.37 | 0.35-0.40 |
| Malignant | 90 | 18 | 0.02 | 0.02-0.03 | 52 | 10 | 0.02 | 0.02-0.03 | 38 | 8 | 0.02 | 0.01-0.03 |
| Non-Malignant | 1,597 | 319 | 0.39 | 0.37-0.41 | 880 | 176 | 0.42 | 0.39-0.45 | 717 | 143 | 0.36 | 0.33-0.38 |
| Tumors of the pineal region | 197 | 39 | 0.05 | 0.04-0.06 | 98 | 20 | 0.05 | 0.04-0.06 | 99 | 20 | 0.05 | 0.04-0.06 |
| Malignant | 157 | 31 | 0.04 | 0.03-0.04 | 87 | 17 | 0.04 | 0.03-0.05 | 70 | 14 | 0.03 | 0.03-0.04 |
| Non-Malignant | 40 | 8 | 0.01 | 0.01-0.01 | -- | -- | -- | -- | 29 | 6 | 0.01 | 0.01-0.02 |
| Embryonal tumors | 2,527 | 505 | 0.62 | 0.59-0.64 | 1,510 | 302 | 0.72 | 0.68-0.76 | 1,017 | 203 | 0.51 | 0.48-0.54 |
| Medulloblastomac | 1,611 | 322 | 0.39 | 0.37-0.41 | 1,024 | 205 | 0.49 | 0.46-0.52 | 587 | 117 | 0.29 | 0.27-0.32 |
| Primitive neuroectodermal tumord | 319 | 64 | 0.08 | 0.07-0.09 | 170 | 34 | 0.08 | 0.07-0.09 | 149 | 30 | 0.07 | 0.06-0.09 |
| Atypical teratoid/rhabdoid tumore | 375 | 75 | 0.09 | 0.08-0.10 | 201 | 40 | 0.10 | 0.08-0.11 | 174 | 35 | 0.09 | 0.07-0.10 |
| Other embryonal histologiesf | 222 | 44 | 0.05 | 0.05-0.06 | 115 | 23 | 0.05 | 0.05-0.07 | 107 | 21 | 0.05 | 0.04-0.06 |
| Tumors of Cranial and Spinal Nerves | 1,202 | 240 | 0.29 | 0.27-0.31 | 633 | 127 | 0.30 | 0.28-0.32 | 569 | 114 | 0.28 | 0.26-0.31 |
| Nerve sheath tumors | 1,199 | 240 | 0.29 | 0.27-0.31 | 630 | 126 | 0.30 | 0.28-0.32 | 569 | 114 | 0.28 | 0.26-0.31 |
| Malignant | 24 | 5 | 0.01 | 0.00-0.01 | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 1,175 | 235 | 0.28 | 0.27-0.30 | 620 | 124 | 0.29 | 0.27-0.32 | 555 | 111 | 0.27 | 0.25-0.30 |
| Other tumors of cranial and spinal nerves | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Tumors of Meninges | 1,054 | 211 | 0.25 | 0.24-0.27 | 521 | 104 | 0.24 | 0.22-0.27 | 533 | 107 | 0.26 | 0.24-0.28 |
| Meningioma | 632 | 126 | 0.15 | 0.14-0.16 | 299 | 60 | 0.14 | 0.12-0.16 | 333 | 67 | 0.16 | 0.15-0.18 |
| Malignant | 32 | 6 | 0.01 | 0.01-0.01 | 17 | 3 | 0.01 | 0.00-0.01 | -- | -- | -- | -- |
| Non-Malignant | 600 | 120 | 0.14 | 0.13-0.16 | 282 | 56 | 0.13 | 0.12-0.15 | 318 | 64 | 0.16 | 0.14-0.17 |
| Mesenchymal tumors | 217 | 43 | 0.05 | 0.05-0.06 | 114 | 23 | 0.05 | 0.04-0.07 | 103 | 21 | 0.05 | 0.04-0.06 |
| Primary melanocytic lesions | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Other neoplasms related to the meninges | 196 | 39 | 0.05 | 0.04-0.05 | 101 | 20 | 0.05 | 0.04-0.06 | 95 | 19 | 0.05 | 0.04-0.06 |
| Lymphomas and Hematopoietic Neoplasms | 122 | 24 | 0.03 | 0.02-0.04 | 75 | 15 | 0.04 | 0.03-0.04 | 47 | 9 | 0.02 | 0.02-0.03 |
| Lymphoma | 55 | 11 | 0.01 | 0.01-0.02 | 36 | 7 | 0.02 | 0.01-0.02 | 19 | 4 | 0.01 | 0.01-0.01 |
| Other hematopoietic neoplasms | 67 | 13 | 0.02 | 0.01-0.02 | 39 | 8 | 0.02 | 0.01-0.03 | 28 | 6 | 0.01 | 0.01-0.02 |
| Germ Cell Tumors and Cysts | 922 | 184 | 0.22 | 0.21-0.24 | 637 | 127 | 0.30 | 0.28-0.33 | 285 | 57 | 0.14 | 0.13-0.16 |
| Germ cell tumors, cysts and heterotopias | 922 | 184 | 0.22 | 0.21-0.24 | 637 | 127 | 0.30 | 0.28-0.33 | 285 | 57 | 0.14 | 0.13-0.16 |
| Malignant | 722 | 144 | 0.18 | 0.16-0.19 | 531 | 106 | 0.25 | 0.23-0.27 | 191 | 38 | 0.10 | 0.08-0.11 |
| Non-Malignant | 200 | 40 | 0.05 | 0.04-0.06 | 106 | 21 | 0.05 | 0.04-0.06 | 94 | 19 | 0.05 | 0.04-0.06 |
| Tumors of Sellar Region | 3,678 | 736 | 0.88 | 0.85-0.91 | 1,175 | 235 | 0.55 | 0.52-0.59 | 2,503 | 501 | 1.22 | 1.17-1.27 |
| Tumors of the pituitary | 2,841 | 568 | 0.67 | 0.65-0.70 | 758 | 152 | 0.35 | 0.33-0.38 | 2,083 | 417 | 1.01 | 0.97-1.06 |
| Malignant | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Non-Malignant | 2,837 | 567 | 0.67 | 0.65-0.70 | 756 | 151 | 0.35 | 0.33-0.38 | 2,081 | 416 | 1.01 | 0.97-1.06 |
| Craniopharyngioma | 837 | 167 | 0.20 | 0.19-0.22 | 417 | 83 | 0.20 | 0.18-0.22 | 420 | 84 | 0.21 | 0.19-0.23 |
| Unclassified Tumors | 1,468 | 294 | 0.35 | 0.34-0.37 | 728 | 146 | 0.34 | 0.32-0.37 | 740 | 148 | 0.37 | 0.34-0.39 |
| Hemangioma | 551 | 110 | 0.13 | 0.12-0.14 | 278 | 56 | 0.13 | 0.12-0.15 | 273 | 55 | 0.13 | 0.12-0.15 |
| Neoplasm, unspecified | 893 | 179 | 0.22 | 0.20-0.23 | 438 | 88 | 0.21 | 0.19-0.23 | 455 | 91 | 0.23 | 0.20-0.25 |
| Malignant | 204 | 41 | 0.05 | 0.04-0.06 | 104 | 21 | 0.05 | 0.04-0.06 | 100 | 20 | 0.05 | 0.04-0.06 |
| Non-Malignant | 689 | 138 | 0.17 | 0.15-0.18 | 334 | 67 | 0.16 | 0.14-0.18 | 355 | 71 | 0.18 | 0.16-0.19 |
| All other | 24 | 5 | 0.01 | 0.00-0.01 | -- | -- | -- | -- | -- | -- | -- | -- |
| TOTAL g | 24,002 | 4,800 | 5.81 | 5.73-5.88 | 12,136 | 2,427 | 5.75 | 5.65-5.86 | 11,866 | 2,373 | 5.87 | 5.76-5.97 |
| Malignant | 14,337 | 2,867 | 3.48 | 3.43-3.54 | 7,829 | 1,566 | 3.72 | 3.64-3.80 | 6,508 | 1,302 | 3.23 | 3.16-3.31 |
| Non-Malignant | 9,665 | 1,933 | 2.32 | 2.28-2.37 | 4,307 | 861 | 2.03 | 1.97-2.10 | 5,358 | 1,072 | 2.63 | 2.56-2.70 |
aAnnual average cases are calculated by dividing the five year total by five.
bRates are per 100,000 and are age-adjusted to the 2000 US standard population.
cICD-O-3 histology codes: 9470/3, 9471/3, 9472/3, 9474/3.
dICD-O-3 histology code: 9473/3.
eICD-O-3 histology code: 9508/3.
fICD-O-3 histology codes: 8963/3, 9364/3, 9480/3, 9490/0, 9490/3, 9500/3, 9501/3, 9502/3.
gRefers to all brain tumors including histologies not presented in this table.
- Counts and rates are not presented when fewer than 16 cases were reported for the specific histology category. Suppressed cases are included in the total counts and rates.
Abbreviations: CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results program; CI, confidence interval; NOS, not otherwise specified.