Table 15.
Five-Year Total, Annual Average Totala, and Age-Adjusted and Age-Specific Incidence Ratesb for Brain and Other Central Nervous System Tumors in Children and Adolescents, (Age 0-19 Years), by International Classification of Childhood Cancer (ICCC),c CBTRUS Statistical Report: NPCR and SEER, 2010-2014
| ICCC Category | 0-14 c years | 0-19 c years | < 1 year | 1-4 years | 5-9 years | 10-14 years | 15-19 years | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Five-Year Total | Annual Average | Rate | 95% CI | Five-Year Total | Annual Average | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | Rate | 95% CI | |
| II Lymphomas and reticuloendothelial neoplasms | 72 | 14 | 0.02 | 0.02-0.03 | 111 | 22 | 0.03 | 0.02-0.03 | -- | -- | -- | -- | 0.03 | 0.02-0.04 | 0.03 | 0.02-0.04 | 0.04 | 0.03-0.05 |
| III CNS and misc. intracranial and intraspinal neoplasms | 14,526 | 2,905 | 4.75 | 4.67-4.83 | 20,223 | 4,045 | 4.89 | 4.83-4.96 | 4.70 | 4.41-5.02 | 5.32 | 5.16-5.48 | 4.56 | 4.43-4.70 | 4.52 | 4.39-4.65 | 5.32 | 5.18-5.46 |
| III(a) Ependymomas and choroid plexus tumor | 1,332 | 266 | 0.43 | 0.41-0.46 | 1,629 | 326 | 0.39 | 0.38-0.41 | 0.98 | 0.85-1.13 | 0.69 | 0.63-0.75 | 0.29 | 0.26-0.32 | 0.28 | 0.25-0.32 | 0.28 | 0.25-0.31 |
| III(b) Astrocytomas | 5,734 | 1,147 | 1.88 | 1.83-1.92 | 7,194 | 1,439 | 1.75 | 1.71-1.79 | 1.39 | 1.23-1.56 | 2.30 | 2.20-2.41 | 1.86 | 1.77-1.94 | 1.67 | 1.59-1.75 | 1.37 | 1.30-1.44 |
| III(c) Intracranial and intraspinal embryonal tumors | 2,113 | 423 | 0.69 | 0.66-0.72 | 2,331 | 466 | 0.57 | 0.54-0.59 | 1.08 | 0.94-1.23 | 1.03 | 0.96-1.10 | 0.65 | 0.61-0.71 | 0.40 | 0.36-0.44 | 0.20 | 0.18-0.23 |
| III(d) Other gliomas | 1,815 | 363 | 0.59 | 0.57-0.62 | 2,324 | 465 | 0.56 | 0.54-0.59 | 0.28 | 0.21-0.36 | 0.58 | 0.53-0.64 | 0.70 | 0.65-0.75 | 0.56 | 0.51-0.61 | 0.48 | 0.44-0.52 |
| III(e) Other specified intracranial and intraspinal neoplasms | 2,919 | 584 | 0.96 | 0.92-0.99 | 5,853 | 1,171 | 1.40 | 1.37-1.44 | 0.65 | 0.54-0.77 | 0.56 | 0.51-0.61 | 0.90 | 0.84-0.96 | 1.37 | 1.30-1.45 | 2.74 | 2.64-2.84 |
| III(f) Unspecified intracranial and intraspinal neoplasms | 613 | 123 | 0.20 | 0.19-0.22 | 892 | 178 | 0.22 | 0.20-0.23 | 0.33 | 0.25-0.42 | 0.16 | 0.14-0.19 | 0.17 | 0.14-0.19 | 0.24 | 0.21-0.27 | 0.26 | 0.23-0.29 |
| IV Neuroblastoma and other peripheral nervous cell tumors | 146 | 29 | 0.05 | 0.04-0.06 | 158 | 32 | 0.04 | 0.03-0.04 | 0.28 | 0.21-0.37 | 0.07 | 0.06-0.10 | -- | -- | 0.02 | 0.01-0.03 | -- | -- |
| IX Soft tissue and other extraosseous sarcomas | 68 | 14 | 0.02 | 0.02-0.03 | 96 | 19 | 0.02 | 0.02-0.03 | -- | -- | 0.02 | 0.01-0.03 | 0.02 | 0.01-0.03 | 0.02 | 0.01-0.03 | 0.03 | 0.02-0.04 |
| X(a) Intracranial & intraspinal germ cell tumors | 645 | 129 | 0.21 | 0.20-0.23 | 922 | 184 | 0.22 | 0.21-0.24 | 0.40 | 0.31-0.49 | 0.11 | 0.08-0.13 | 0.17 | 0.14-0.19 | 0.31 | 0.27-0.34 | 0.26 | 0.23-0.29 |
| All other categories | 17 | 3 | 0.01 | 0.00-0.01 | 25 | 5 | 0.01 | 0.00-0.01 | -- | -- | -- | -- | -- | -- | -- | -- | -- | -- |
| Not classified by ICCC | 1,464 | 293 | 0.48 | 0.46-0.50 | 2,464 | 493 | 0.59 | 0.57-0.62 | 0.75 | 0.63-0.88 | 0.44 | 0.39-0.48 | 0.40 | 0.36-0.44 | 0.55 | 0.50-0.59 | 0.93 | 0.88-0.99 |
| TOTAL e | 16,941 | 3,388 | 5.54 | 5.46-5.63 | 24,002 | 4,800 | 5.81 | 5.73-5.88 | 6.19 | 5.85-6.55 | 5.98 | 5.81-6.15 | 5.19 | 5.05-5.33 | 5.44 | 5.30-5.58 | 6.59 | 6.44-6.75 |
aAnnual average cases are calculated by dividing the five year total by five.
bRates are per 100,000.
cSee Supplementary Table 1 for additional information on this classification scheme.
dRates are age-adjusted to the 2000 U.S. standard population.
eRefers to all brain tumors including histologies not presented in this table.
-Counts and rates are not presented when fewer than 16 cases were reported for the specific ICCC category. The suppressed cases are included in the counts and rates for totals.
Abbreviations: ICCC, International Classification of Childhood Cancer; CBTRUS, Central Brain Tumor Registry of the United States; NPCR, National Program of Cancer Registries; SEER, Surveillance, Epidemiology, and End Results program; CI, confidence interval.