Fig 4. Biomechanical properties in Gja1^–/+ and Sost^–/+ mutant mice.

Polar moment of inertia (pMOI) at 1 (A) and 3 (B) months of age measured by μCT analysis of the tibia as in Fig 2 (n = 7–14 per group). Three-point bending biomechanical testing in femurs of 3 month old mice, reporting ultimate force (C), fracture force (D), and stiffness (E) (n = 6–12 per group). * p<0.05 and **p<0.01 relative to WT in Dunnett’s test for multiple comparisons in ANOVA.