. Author manuscript; available in PMC: 2018 Dec 1.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2017 Nov 8;44(6):631–640. doi: 10.1007/s10928-017-9554-9

Table 1.

Pharmacokinetic Parameters and associated variability used to simulate the 100 datasets (Full Model).

Parameter	Value	%CV
Clearance: CL (L/hr)	47.3	21.1
Central Volume: Vc (L)	144
Intercompartmental Clearance: Q (L/hr)	186
Peripheral Volume: Vp (L)	971
Absorption Rate Constant: Ka (hr-1)	0.741
Clearance In, Tissue-1: CL_t1 (L/hr)	1.83	25
Clearance, Tissue-1 to Tissue-2: CL_t2(L/hr)	0.0924	64.5
Transfer Rate, Tissue-2 to Central: Ktr (hr-1)	0.0152	36.7
Tissue Volume: Vt(L)	0.749
Residual Variability
Plasma Proportional Error	7.8%
Tissue-1 Exponential Error	56%