. Author manuscript; available in PMC: 2018 Dec 1.

Published in final edited form as: J Pharmacokinet Pharmacodyn. 2017 Nov 8;44(6):631–640. doi: 10.1007/s10928-017-9554-9

Table 2.

Summary of normalized prediction error (NPE) and absolute normalized prediction error (ANPE) expressed as a percentage value for both estimation methods.

Sample Design	Method	NPE: Median [Min, Max] (%)	ANPE : Median [Min, Max] (%)	ANPE ≥ 30% (% of dataset)	ANPE ≥ 50% (% of dataset)
4×8	NLME	−8.7 [−35, 30]	13.1 [0.1, 35]	7	0
4×8	Bootstrap	−0.1 [−36, 115]	17.1 [0.4, 115]	20	10
3×7	NLME (25%CV Residual Error)	−9.3 [ −45, 52]	14.7 [0.7, 52]	12	1
	NLME (45% CV Residual Error)	−7.1 [−47,76]	17.0 [0.7,76]	16	1
	Bootstrap	3.5 [−48, 119]	17.2 [0.1, 119]	26	11