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. Author manuscript; available in PMC: 2017 Nov 17.
Published in final edited form as: Oncogene. 2016 Sep 12;36(10):1374–1383. doi: 10.1038/onc.2016.301

Figure 2. MDM2C305F mutation increases prevalence of APC loss-induced colon cancer.

Figure 2

A. Colon tissue was isolated from 15 week-old mice, and polyp numbers per mouse were counted under a dissection microscope. Error bars, ±SEM; *P<0.05.

B. The average size of colonic polyps in each genotype (n=12 mice). Apcmin/+; Mdm2m/m mice had significantly more large (>4mm) polyps. Error bars, ±SEM; *P<0.05.

C. The average cross sectional areas (CSA) of H&E stained colon adenomas were determined quantitatively using ImageJ. Error bars, ±SEM; *P<0.05.

D. The incidence of colon tumors in each genotype (n=12), measured by percentage of mice with observed colon tumors.

E. Pictures show the colonic polyps from Apcmin/+; Mdm2+/+ or Apcmin/+; Mdm2m/m mice under a dissection microscope. Adenomas from Apcmin/+; Mdm2m/m mice appeared significantly larger.

F. Representative H&E stained sections from Apcmin/+; Mdm2+/+ or Apcmin/+; Mdm2m/m mouse colon (Normal) and colon adenoma (Tumor) tissue. Scale bar = 500μm.