Table 2.
Risk factors
| Risk factor at the time of RSV infectious episode | URTI episodes (n=30) | LRTI episodes (n=7) | P-value |
|---|---|---|---|
| Concurrent respiratory infections at the time of infection | 8 (27%) | 6 (86%) | 0.007 |
| Concurrent GVHD at the time of infection | 4 (13%) | 0 | 0.57 |
| Immunosuppressive medications at the time of infection | 0.94 | ||
| Steroids alone | 5 (17%) | 1 (14%) | |
| Steroids+CSA, tacrolimus or MMF | 12 (40%) | 2 (29%) | |
| Cyclosporine±other | 3 (10%) | 1 (14%) | |
| Chemotherapy | 1 (3%) | 0 | |
| None | 9 (30%) | 3 (43%) | |
| Dose of steroids at the time of infection | |||
| Methylprednisolone or prednisone | Median 0.8 mg/kg per day (range 0.1–4.3) | Median 0.6 mg/kg per day (range 0.4–1.4) | 0.65 |
| Dexamethasone | 0.15 mg/kg per day | — | — |
| Risk factor for patients with RSV infections | Patients with URTI (n=26) | Patients with LRTI (n=6) | |
|---|---|---|---|
| Days post HSCT when RSV was first identified | Median 151 (range 3–1085) | Median 257 (range 10–1669) | 0.79 |
| Age at the time RSV was first identified | Median 6.1 (range 1.1–26.4) | Median 9 (range 0.6–21.6) | 0.80 |
| <2 years of age at the time RSV was first identified | 2 (8%) | 2 (33%) | 0.23 |
| ANC (cells per mm3) at the time RSV was first identified | Median 1840 (range 0–8360) | Median 5340 (range 640–10 530) | 0.15 |
| ALC (cells per mm3) at the time RSV first identified | Median 390 (range 0–7240) | Median 150 (range 60–1680) | 0.65 |
| Number of patients with ALC <200 cells per mm3 at the time RSV was first identifed | 9 (35%) | 2 (33%) | 1.0 |
Abbreviations: ALC=absolute lymphocyte count; CSA=cyclosporin A; LRTI=lower respiratory tract infection; RSV=respiratory syncytial virus; URTI=upper respiratory tract infection.