Three-way Interaction of Neuroticism, Extraversion, and Conscientiousness in the Internalizing Disorders: Evidence of Disorder Specificity in a Psychiatric Sample

. Author manuscript; available in PMC: 2018 Oct 1.

Published in final edited form as: J Res Pers. 2017 May 18;70:16–26. doi: 10.1016/j.jrp.2017.05.003

	NEO PI-3FH			PID-5
	Model R² (R)	ΔR²_3-way	B (SE)	Model R² (R)	ΔR²_3-way	B (SE)
*MDD*	.338^*** (.581)	.012^*		.412^*** (.642)	.014^***
Gender			−.27 (.30)			.39 (.22)
Neuroticism/Negative Affectivity			1.85^*** (.28)			.47^*** (.07)
Extraversion/Detachment			−1.13^*** (.33)			.55^*** (.08)
Conscientiousness/Disinhibition			−.41 (.29)			.30^*** (.09)
N/NA X E/Det			.06 (.44)			.03 (.04)
N/NA X C/Dis			−.17 (.38)			.05 (.04)
C/Dis X E/Det			.16 (.53)			.00 (.05)
N/NA X E/Det X C/Dis			−1.24^* (.58)			−.05^*** (.01)
*PDD*	.241^*** (.491)	.001		.344^*** (.587)	.001
Gender			.56 (.31)			.85^*** (.21)
Neuroticism/Negative Affectivity			1.13^*** (.29)			.31^*** (.07)
Extraversion/Detachment			−1.06^** (.33)			.47^*** (.08)
Conscientiousness/Disinhibition			−.17 (.30)			.19^* (.09)
N/NA X E/Det			.37 (.45)			.03 (.04)
N/NA X C/Dis			.28 (.39)			−.02 (.04)
C/Dis X E/Det			.36 (.54)			−.02 (.05)
N/NA X E/Det X C/Dis			−.26 (.64)			−.01 (.01)
*Panic*	.152^*** (.390)	.003		.156^*** (.394)	.002
Gender			1.35 (.75)			.92 (.57)
Neuroticism/Negative Affectivity			3.12^*** (.70)			1.05^*** (.19)
Extraversion/Detachment			−1.37 (.81)			.46^* (.21)
Conscientiousness/Disinhibition			1.34 (.73)			−.12 (.23)
N/NA X E/Det			.45 (1.10)			−.10 (.12)
N/NA X C/Dis			.93 (.95)			−.01 (.10)
C/Dis X E/Det			1.11 (1.33)			.19 (.14)
N/NA X E/Det X C/Dis			−1.33 (1.56)			−.04 (.04)
*Agoraphobia*	.037 (.193)	.001		.069^*** (.262)	.002
Gender			−.00 (.20)			−.04 (.16)
Neuroticism/Negative Affectivity			.29 (.19)			.19^*** (.05)
Extraversion/Detachment			−.36 (.21)			.11 (.06)
Conscientiousness/Disinhibition			.08 (.19)			−.04 (.06)
N/NA X E/Det			.05 (.29)			.04 (.03)
N/NA X C/Dis			.17 (.25)			−.03 (.03)
C/Dis X E/Det			.28 (.35)			.02 (.04)
N/NA X E/Det X C/Dis			−.25 (.41)			−.01 (.01)
*Social Anxiety*	.248^*** (.498)	.000		.237^*** (.487)	.000
Gender			−.18 (.20)			−.18 (.15)
Neuroticism/Negative Affectivity			1.05^*** (.19)			.31^*** (.05)
Extraversion/Detachment			−.48^* (.22)			.11^* (.05)
Conscientiousness/Disinhibition			.14 (.20)			.04 (.06)
N/NA X E/Det			−.47 (.29)			.05 (.03)
N/NA X C/Dis			.11 (.25)			−.01 (.03)
C/Dis X E/Det			−.17 (.35)			−.02 (.04)
N/NA X E/Det X C/Dis			−.12 (.41)			−.00 (.01)
*OCD*	.001^*** (.318)	.000		.133^*** (.365)	.002
Gender			−.13 (.12)			−.06 (.09)
Neuroticism/Negative Affectivity			.43^*** (.11)			.09^** (.03)
Extraversion/Detachment			−.01 (.13)			−.02 (.03)
Conscientiousness/Disinhibition			.07 (.12)			.06 (.03)
N/NA X E/Det			−.06 (.18)			.03 (.02)
N/NA X C/Dis			.10 (.15)			.02 (.02)
C/Dis X E/Det			.16 (.21)			−.02 (.02)
N/NA X E/Det X C/Dis			.07 (.25)			.01 (.01)
*PTSD*	.269^*** (.519)	.008		.424^*** (.651)	.012^***
Gender			−.12 (.65)			.87^* (.44)
Neuroticism/Negative Affectivity			3.33^*** (.61)			1.02^*** (.15)
Extraversion/Detachment			−1.88^** (.70)			.97^*** (.16)
Conscientiousness/Disinhibition			−.63 (.63)			.66^*** (.17)
N/NA X E/Det			1.47 (.95)			.01 (.09)
N/NA X C/Dis			1.07 (.81)			−.10 (.08)
C/Dis X E/Det			2.55^* (1.14)			.24^* (.10)
N/NA X E/Det X C/Dis			−2.17 (1.34)			−.09^** (.03)
*GAD*	.298^*** (.546)	.015^*		.310^*** (.557)	.002
Gender			.73^* (.29)			.71^*** (.21)
Neuroticism/Negative Affectivity			2.02^*** (.27)			.59^*** (.07)
Extraversion/Detachment			−.44 (.31)			.07 (.08)
Conscientiousness/Disinhibition			.38 (.28)			.07 (.08)
N/NA X E/Det			.59 (.42)			−.02 (.04)
N/NA X C/Dis			.29 (.36)			−.09^* (.04)
C/Dis X E/Det			.75 (.51)			.13^* (.05)
N/NA X E/Det X C/Dis			−1.37^* (.59)			−.02 (.01)

Note. N = 255–260 for the NEO PI-3FH analyses and 445–454 for PID-5 analyses. Unstandardized regression weights from the final step of each model are shown. Gender was coded as 1 = male, 2 = female.

p < .05,

^**

p < .01,

^***

p < .001.