Fig 5. Thalamic lag structure in early childhood vs. adult wake/sleep.

(A) Whole thalamus seed-region. (B) Thalamus-seeded lag maps in adult wake (N0) and slow wave sleep (N3). As previously published, cortex is generally late (red) with respect to thalamus during wake, but generally early (blue) with respect to thalamus during N3 sleep. (C) Thalamus-seeded lag maps in early childhood. The 6-month old lag map shows most of cortex is late with respect to thalamus, akin to adult wake. In contrast, the 24-month old lag map shows most of cortex is early with respect to thalamus, akin to adult N3 sleep. (D) Thalamic lag map in sleeping 6-month olds is significantly more correlated with adult wake than adult sleep, whereas the opposite is true for sleeping 24-month olds; * = p < 0.01 from permutation resampling on adult N0 vs. N3 lag projections with Bonferroni correction for multiple comparisons. No statistically significant difference was found at 24-months.