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. 2017 Nov 16;14:223. doi: 10.1186/s12974-017-0994-3

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 13 — Peripheral immune tolerance pre-treated PD rats were protected from intracranial LPS injection-induced neurodegeneration with improved behavioral impairment. Rats from the control group, the PBS (striatum) group, the PBS (i.p.) + LPS (striatum) group, and the LPS (i.p.) + LPS (striatum) group were administrated a single dose of amphetamine (5 mg/kg) on day 28 post to intracranial injection, and the numbers of ipsilateral turns were recorded with 120 min. The results showed alleviated behavioral impairment caused by peripheral LPS pre-treatment. a The numbers of ipsilateral turns per minutes for 120 min after the amphetamine injection. b The total numbers of ipsilateral turns within 120 min after the amphetamine injection. ***P < 0.001 vs. control group. ###P < 0.001 vs. PBS (i.p.) + LPS (striatum) group. The data are presented as the mean ± SEM (n = 6)