Fig. 5.

Peripheral immune tolerance preconditioning decreased intracranial LPS injection-induced production of TNF-α and IL-1β in the SN. Rats from four groups with or without peripheral LPS pre-treatment were sacrificed, and right SN was dissected out at time point of 1, 7, 14, and 28 days after striatal LPS injection for ELISA analysis. The results showed that the production of TNF-α and IL-1β were decreased by peripheral LPS preconditioning at 1, 7, and 14 days after the intracranial LPS exposure. a–f The expression of TNF-α (a–c) and IL-1β (d–f) in the right SN were detected by ELISA at 1, 7, and 14 days. The difference was imperceptible at 28 days, so the data was not shown.*P < 0.05, ***P < 0.001 vs. control group. ##P < 0.01, ###P < 0.001 vs. PBS (i.p.) + LPS (striatum) group. The data are presented as the mean ± SEM (n = 7)