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. 2017 Nov 17;17:199. doi: 10.1186/s12883-017-0980-5

Table 4.

Univariate and Multivariable Analysis for Biochemical Predictors of PSD in Patients With ACI

Univariate Multivariate
OR (95% CI) P value OR (95% CI) P value
TT3, μg/L 0.00(0.000,0.04) < 0.001#
TT4, μg/L 0.99(0.95,1.03) 0.582
TSH, uIU/mL 1.15(0.66,2.03) 0.625
LDL, mmol/L 0.89(0.56,1.41) 0.618
HDL, mmol/L 0.66(0.17,2.56) 0.438
FBG, mmol/L 1.11(0.90,1.36) 0.337
2hPBG, mmol/L 1.03(0.94,1.13) 0.543
HbA1c, % 0.97(0.74,1.26) 0.790
NE, ng/L 0.99(0.99,0.99) < 0.001#
DA, ng/L 0.85(0.79,0.90) < 0.001# 0.64(0.45,0.91) 0.014*
5-HT, ng/L 0.99(0.99,1.00) < 0.001# 0.99(0.98,1.00) 0.046*
IL-6, ng/L 3.23(1.90,5.48) < 0.001#
TNF-α, ng/L 1.03(1.02,1.04) < 0.001# 1.05(1.00,1.09) 0.044*
NGF, ng/L 0.55(0.41,0.76) < 0.000# 0.06(0.01,0.67) 0.022*
CGRP, pg/ml 1.03(0.99,1.07) 0.146

CI confidence interval, CGRP calcitonin gene-related peptide, DA dopamine, FBG fasting blood glucose, 5-HT 5-hydroxytryptamine, HbA1c glycosylated hemoglobin, type A1c, HDL high-density lipoprotein, IL-6 interleukin 6, LDL low-density lipoprotein, NE norepinephrine, NGF nerve growth factor, OR odds ratio, 2hPBG 2-h postprandial blood glucose, PSD post-stroke depression, SD standard deviation, TNF-α tumor necrosis factor-α, TSH thyroid-stimulating hormone, TT3 total triiodothyronine, TT4 total thyroxine

* P < 0.05; # P < 0.001