Fig. 5. Comparison of lumen-side oxidized residues detected by Bricker and co-workers (11, 13) and in the current study.

(A) Lumen-side oxidized residues detected on the D1 and D2 proteins in the study by Kale et al. (11) and in arm 1 in this study and their correspondence to channel 3 (26). (B) D1/D2 arm 1 residues in this study and the additional oxidized CP47 residues identified in a targeted analysis based on the results of Frankel et al. (13) and their correspondence to channel 3 (26, 27). (C) Oxidized residues in the arm 3 region detected by Frankel et al. (13) and in the current study. Note: Some additional lumen-side residues detected by Frankel et al. (13) that are not relevant to this discussion are not shown in this figure. Gray, residues only found oxidized by Bricker and co-workers (11, 13); orange (A) and purple (C), residues found oxidized in the studies by Kale et al. (11) or Frankel et al. (13), respectively, and the current study; red, D1/D2 arm 1 residues; yellow, Cl⁻ (B) and arm 3 residues (C); cyan, channel 3 (26); green, Mn cluster.