Histological characteristics of 28 d and 70 d wild-type, mdx and mdx taurine mice.

Representative haemotoxylin and eosin stained transverse sections of tibialis anterior muscles from 28 and 70 d WT, mdx and mdx tau mice shown at 400X magnification. Nuclei are stained dark, cytoplasm pink/orange. Fiber outlines are evident, non-contractile tissue (NCT) are indicated, and centrally nucleated fibers (CNF), scale bars = 100 µm. B. Quantification of the percentage area of NCT (B) and CNF (C) for 28 d (black bars) and 70 d (white bars) WT, mdx and mdx tau mice. Lines above specific bars indicate significant difference (p<0.05), One way ANOVA with Sidak’s post-hoc analyses. Data presented as means + SD, n = 4 all groups.