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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Bioorg Med Chem Lett. 2017 Oct 25;27(23):5163–5166. doi: 10.1016/j.bmcl.2017.10.056

Fig. 3.

Fig. 3

A) Relative inhibitory activity for EPAC1-mediated Rap1b-bGDP exchange. B) Relative inhibitory activity for EPAC2-mediated Rap1b-bGDP exchange. Dose-dependent inhibition of EPAC1/2 GEF activity by compounds 5, 6, 14, and 31, in the presence of 20 μM cAMP. Relative GEF activity were presented as normalized reaction rate constant (means ± SEM, n =3) described in the method.