Table 3.

Association between accelerated knee osteoarthritis (AKOA) and knee injury prior to onset of disease

	No KOA n = 787	AKOA n = 69	Odds Ratio (95% CI)
Injury After 48-months but before endpoint	97 (12%)	28 (41%)	4.86 (2.87, 8.22)
Number of Prior Injuries:
0 injuries	631 (80%)	38 (55%)	REFERENCE
1 injury	103 (13%)	23 (33%)	3.71 (2.12, 6.48)
2 injuries	32 (4%)	7 (10%)	2.51 (1.11, 5.65)
3 or more injuries	21 (3%)	1 (1%)	combined with 2 injuries for analyses
Most Recent Injury Prior to Endpoint:
No injury within 4 years	690 (88%)	39 (57%)	REFERENCE
Within 2 years of endpoint	57 (7%)	20 (29%)	6.21 (3.40, 11.35)
Between 2 and 4 years of endpoint	40 (5%)	10 (14%)	4.42 (2.06, 9.50)

Sample size is limited to those with complete injury data.

For adults with no KOA we considered injury to either knee. Number of prior injuries is based on the number of years a person reported an injury.