Table 1.

Characteristics of three particle forms delivering the same deposited dose per surface area in G13.

	2.64 μm Microparticles	2.64 μm Nanoaggregates	50 nm Nanoaerosols
Particle density (BD and FP) [g/cm3]	1.3	1.3	1.3
Mass of 1 particle [ng]	0.01252	0.01252 each nanoaggregatea	8.51E-8
Integer number of particles in airway	6	6 nanoaggregatesb 147,121 nanoparticles each	882,726
Number of simulated parcels	6	600	24,000
Number of particles per parcel	1	1471	36.8
Total drug mass deposited in airway [ng]	0.0751	.0751	0.0751
Deposited dose per surface area [ng/cm2]	1.22c	1.22	1.22

Surface area of one G13 airway: 0.06158 cm² Deposited dose based on CFD estimates: 1.3 ng/cm²

^aPacking fractions are not included

^bNanoparticles composing the nanoaggregates have a diameter of 50 nm

^cValue is different from the target of 1.3 ng/cm² due to the need of an integer number of microparticles