Table 2.
Model estimates of eGFR trajectory
eGFR Estimate |
SE | p value | |
---|---|---|---|
a. Estimates of eGFR Trajectory and Trajectory Change | |||
Non-diabetic donors related to recipient with donation eGFR of 105 mL/min/1.73m2 | |||
First 15 years post-donation | 0.27 | 0.03 | <0.001 |
> 15 years post-donation | −0.27 | 0.04 | <0.001 |
Difference in eGFR change (diabetic vs. non-diabetic) | |||
In the 7 years prior to DM diagnosis | −0.08 | 0.12 | 0.51 |
After DM diagnosis | |||
Hypertension, Proteinuria | −1.10 | 0.32 | <0.001 |
Hypertension, No Proteinuria | −0.19 | 0.18 | 0.29 |
No Hypertension, Proteinuria | −0.75 | 0.57 | 0.19 |
No Hypertension, No Proteinuria | −0.09 | 0.20 | 0.63 |
b. Model Parameter Estimates | |||
Age at donation (per 10 years) | −4.55 | 0.21 | <0.001 |
Female | 2.63 | 0.43 | <0.001 |
BMI (per 1 unit) | −0.61 | 0.06 | <0.001 |
Donation year (per decade) | 2.91 | 0.21 | <0.001 |
Donation glucose (per 10mg/dL) | 0.08 | 0.15 | 0.61 |
Donation eGFR (per 10 ml/min/1.73m2) (at time zero) | 2.39 | 0.12 | <0.001 |
LRD (at time zero) | 0.56 | 0.61 | 0.36 |
DM as cause of recipient ESRD | 0.11 | 0.44 | 0.80 |
Smoking | 2.67 | 0.49 | <0.001 |
White | −0.75 | 1.00 | 0.46 |
Interaction of time from donation and LRD | −0.40 | 0.06 | <0.001 |
Interaction of time from donation and donation eGFR | −0.00 | 0.00 | <0.001 |