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. Author manuscript; available in PMC: 2018 Sep 1.
Published in final edited form as: Cancer Metastasis Rev. 2017 Sep;36(3):547–555. doi: 10.1007/s10555-017-9684-y

Figure 2.

Figure 2

Tile map of a breast cancer section showing histologic homogeneity within a heterogeneous tumor milieu. Note the preservation of orderly ecosystems as defined by areas composed of individual histologic subtypes, (a) hyperplasia, (b) DCIS, and (c) invasive cancer within a complex and heterogeneous tumor milieu, implicating their origination from separate progenitors. Also note the heterogeneity in the stromal microenvironments surrounding each ecosystem (denoted by arrow) that implicate their roles in generation/maintenance of tumor heterogeneity.