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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Ann Biomed Eng. 2017 Sep 18;45(12):2813–2825. doi: 10.1007/s10439-017-1917-2

Figure 6.

Figure 6

Linear correlations between strain and SP expression with and without integrin inhibition. (a) Representative images show the mapping between regional strain (dashed line box) and the local SP assessment (solid line box) from the same subregion of an NCC. Linear regressions of normalized SP expression against regional strain reveal only a (b) significant correlation in the case without inhibition of the 2 1 integrin; (c)–(e) there is no significant association after treatment with 10, 100 or 1000 M of the TC-I15 inhibitor. Data points represent 11 untreated NCCs (n=5 loaded; n=6 unloaded) in (b), 7 NCCs treated with 10μM TC-I15 (n=4 loaded; n=3 unloaded) in (c), 8 NCCs treated with 100μM TC-I15 (n=5 loaded; n=3 unloaded) in (d), and 8 NCCs treated with 1000μM TC-I15 (n=5 loaded; n=3 unloaded) in (e).