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Drug transport variants that influence TKI response in CML patients
| Genes | Variants | Drugs | References |
|---|---|---|---|
| ABCB1 | 1263 (TT), (CT/TT) 2677 (TT/TA), (G) 3435 (TT), (CC) |
Imatinib | [50–53] |
| ABCG2 | 34 (G>A) 421 (C>A) |
Imatinib Dasatinib Nilotinib |
[65, 66] |
| SLC22A1 | rs3798168, rs628031 IVS7+850 (C>T) 480 (C>G) 401 (G/A) |
Imatinib | [72–74] |
| SLC22A4 | rs1050152 | Imatinib | [80] |
| SLCO1A2 | 361 (GG) | Imatinib | [78] |
| SLCO1B3 | 334 (GG), (TT) 699 (GG) |
Imatinib | [77, 79] |
| ABCA3 | 4548–91 (CC/CA) | Imatinib | [79] |
