Docking modules within the ARP2/3 complex using connectivity restraints. After encoding the structures of the nucleating module (NM) and the actin localization module (ALM), we tested the global CCS in conjunction with various sets of connectivity restraints (left panels, A, B, and C) for their ability to restraint the docking location and pose of NM on ALM. Structural ensembles were evaluated by hierarchical clustering and the structural families, kernel density functions, and RMSD distributions from the reference are provided.