Table 3.
Ethnic Differences In FEV1 Percent Predicted By PERT Use, F508del copies, and CFTR Mutation Class
| FEV1 In Hispanic Patients |
FEV1 In Non-Hispanic White Patients |
Difference In FEV1 Percent Predicted |
95% CI | p-value | |
|---|---|---|---|---|---|
| Pancreatic Enzyme Replacement | |||||
|
| |||||
| Yes | 79.3% | 85.3% | −6.0% | −6.6% to −5.3% | <0.001 |
| No | 87.7% | 91.8% | −4.1% | −5.0% to −3.2% | <0.001 |
|
| |||||
| F508del Copies | |||||
|
| |||||
| Homozygote | 79.8% | 85.1% | −5.3% | −7.0% to −5.6% | <0.001 |
| Heterozygote | 80.8% | 86.3% | −5.7% | −6.5% to −4.6% | <0.001 |
| No Copies | 81.1% | 88.7% | −7.6% | −8.3% to −7.0% | <0.001 |
|
| |||||
| CFTR Mutation Class | |||||
|
| |||||
| Class I–III | 79.0% | 85.1% | −6.1% | −7.0% to −5.3% | <0.001 |
| Class IV–V | 87.8% | 93.7% | −5.9% | −7.7% to −4.0% | <0.001 |
| Unclassified | 81.8% | 87.5% | −5.7% | −6.5% to −5.0% | <0.001 |
a)
F508del copies were defined as homozygotes, heterozygotes, or no copies. CFTR mutation class was defined as CFTR class I–III, CFTR class IV–V, and unclassified.
b)
Models included the variable of interest (PERT use, F508del copies, or CFTR mutation class) with ethnicity interaction, adjusted for age, sex, PERT, BMI, sweat chloride concentration, MRSA, Pseudomonas aeruginosa, maternal education level, insurance type, tobacco exposure, age at diagnosis, CF-related diabetes, CFTR mutation class, and location in U.S.