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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: Dev Neurobiol. 2017 Sep 19;77(12):1351–1370. doi: 10.1002/dneu.22535

Figure 3.

Figure 3

Regulation of ER positioning at growth cones on CSPGs by PI3K signaling. (A) Examples of the distribution of the ER, as revealed by ER tracker labeling, in distal axons on CSPGs treated with the PI3K activating peptide PI3Kpep or the inactive control peptide PI3KpepAla. Arrows denote the distal most ER accumulation. (B) Quantification of the distance of the distal most ER peak relative to the tip of the axon, as in Figure 1J, on CSPGs with PI3Kpep or PI3KpepAla treatment. (C) Quantification of the distance of the distal most ER peak relative to the tip of the axon on the control substratum following treatment with DMSO or the PI3K inhibitor LY294002. (D) Quantification of the distance of the distal most ER peak relative to the tip of the axon and Mito-Tip on CSPGs following treatment with the ROCK inhibitor Y27632. Samples sizes are denoted in the bars.