Table 3.
Hazard Ratios (95%CI) for all-cause, cardiovascular and cancer mortality by chronic hepatitis C status in the U.S. adult population (NHANES III 1988–1994 and NHANES 1999–2012) (follow-up to December 31, 2011)
| Unweighted N | No CHC 35,671 | CHC 527 |
|---|---|---|
| All-Cause Mortality | ||
|
| ||
| Deaths, un-weighted n | 5,873 | 115 |
| Hazard Ratio (95%CI) | ||
| Unadjusted | 1 [Reference] |
3.47 (2.56–4.70) |
| Model 1a | 1 [Reference] |
2.93 (2.15–3.98) |
| Model 2b | 1 [Reference] |
2.45 (1.81–3.31) |
| Model 3c | 1 [Reference] |
2.44 (1.80–3.30) |
|
| ||
| Cardiovascular and cerebrovascular disease mortality | ||
|
| ||
| Deaths, un-weighted n | 1,782 | 18 |
| Hazard Ratio (95%CI) | ||
| Unadjusted | 1 [Reference] |
2.55 (1.38–4.71) |
| Model 1a | 1 [Reference] |
2.18 (1.18–4.03) |
| Model 2b | 1 [Reference] |
1.87 (1.03–3.42) |
| Model 3 c | 1 [Reference] |
1.85 (1.03–3.33) |
|
| ||
| All Cancer mortality | ||
|
| ||
| Deaths, un-weighted n | 1,346 | 21 |
| Hazard Ratio (95%CI) | ||
| Unadjusted | 1 [Reference] |
1.75 (0.90–3.40) |
| Model 1a | 1 [Reference] |
1.46 (0.75–2.85) |
| Model 2b | 1 [Reference] |
1.16 (0.60–2.25) |
| Model 3c | 1 [Reference] |
1.16 (0.60–2.24) |
a
Model 1: Adjusted for age, age squared, sex, race/ethnicity, education
b
Model 2: Further adjusted for alcohol consumption (never, low, moderate consumption) and smoking (never, former, current)
c
Model 3: Further adjusted for diabetes (yes, no), hypertension (yes, no), albuminuria (yes, no), BMI (WHO categories)