Table 2.
Hazard Ratios (HRs) and 95% confidence intervals (CIs) for risk of skin cancers in relation to personal history of endometriosis, E3N cohort 1990–2008 (n=87,428)
| Personal history of endometriosis | n | Cases | Age-adjusted HR (95% CI) |
Multivariable HRa (95% CI) |
Multivariable HRb (95% CI) |
|---|---|---|---|---|---|
| All skin cancers (n=2,494) | |||||
|
| |||||
| No | 84,461 | 2385 | 1.00 | 1.00 | 1.00 |
| Yes | 2967 | 109 | 1.39 (1.15–1.68) | 1.28 (1.06–1.56) | 1.28 (1.05–1.55) |
|
| |||||
| Melanoma (n=535) | |||||
|
| |||||
| No | 84,461 | 503 | 1.00 | 1.00 | 1.00 |
| Yes | 2967 | 32 | 1.85 (1.30–2.65) | 1.66 (1.16–2.37) | 1.64 (1.15–2.35) |
|
| |||||
| Non-melanoma skin cancers (n=1,959) | |||||
|
| |||||
| No | 84,461 | 1882 | 1.00 | 1.00 | 1.00 |
| Yes | 2967 | 77 | 1.26 (1.00–1.58) | 1.17 (0.93–1.47) | 1.17 (0.93–1.46) |
| Basal Cell Carcinoma (n=1,712) | |||||
| No | 84,461 | 1644 | 1.00 | 1.00 | 1.00 |
| Yes | 2967 | 68 | 1.25 (0.98–1.60) | 1.17 (0.92–1.49) | 1.16 (0.91–1.48) |
| Squamous Cell Carcinoma (n=247) | |||||
| No | 84,461 | 238 | 1.00 | 1.00 | 1.00 |
| Yes | 2967 | 9 | 1.28 (0.66–2.49) | 1.21 (0.62–2.36) | 1.21 (0.62–2.36) |
CI: Confidence Interval; E3N: Etude Epidémiologique auprès de femmes de l’Education Nationale; HR: Hazard Ratio
a
Stratified on birth cohort and adjusted for age, education, hair colour, skin complexion, number of naevi, freckling, skin sensitivity to sun exposure, and family history of skin cancer
b
Additionally adjusted for quartiles of residential sun exposure in county of birth and at baseline