Table 1.
Patient Outcomes
| Binary Outcomes | CIPNM Subjects n (%) | Non-CIPNM Subjects n (%) | Odds Ratio (95% CI) | p-value |
|---|---|---|---|---|
| In hospital mortality | ||||
| Unadjusted Model | 497/3,567 (13.9%) | 180,472/2,807,147 (6.4%) | OR: 2.36 (2.14–2.59) | <.0001 |
| Matched Subjects: Unadjusted Model | 472/3,436 (13.7%) | 630/3,436 (18.3%) | OR: 0.7 (0.62–0.8) | <.0001 |
| Matched Subjects: Model Adjusted using Unbalanced Covariates | 472/3,436 (13.7%) | 630/3,436 (18.3%) | OR: 0.69 (0.6–0.79) | <.0001 |
| Discharge location (home vs elsewhere) | ||||
| Unadjusted Model | 545/3,567 (15.3%) | 1,911,455/2,807,147 (68.1%) | OR: 0.09 (0.08–0.09) | <.0001 |
| Matched Subjects: Unadjusted Model | 527/3,436 (15.3%) | 1,128/3,436 (32.8%) | OR: 0.35 (0.31–0.4) | <.0001 |
| Matched Subjects: Model Adjusted using Unbalanced Covariates | 527/3,436 (15.3%) | 1,128/3,436 (32.8%) | OR: 0.35 (0.31–0.4) | <.0001 |
| Readmitted within 30 days of discharge | ||||
| Unadjusted Model | 315/3,567 (8.83%) | 152,764/2,807,147 (5.44%) | OR: 1.68 (1.5–1.89) | <.0001 |
| Matched Subjects: Unadjusted Model | 305/3,436 (8.88%) | 273/3,436 (7.95%) | OR: 1.13 (0.95–1.34) | 0.16 |
| Matched Subjects: Model Adjusted using Unbalanced Covariates | 305/3,436 (8.88%) | 273/3,436 (7.95%) | OR: 1.13 (0.95–1.35) | 0.16 |
| Continuous Outcomes | CIPNM Subjects Mean (StdErr) | Non-CIPNM Subjects Mean (StdErr) | Difference (95% CI) | p-value |
| Hospital days | ||||
| Unadjusted Model | 31.77 (0.15) | 6.89 (0.005) | 24.87 (24.59–25.16) | <.0001 |
| Matched Subjects: Unadjusted Model | 31.23 (0.45) | 25 (0.42) | 6.22 (5.13–7.32) | <.0001 |
| Matched Subjects: Model Adjusted using Unbalanced Covariates | 29.59 (0.39) | 23.81 (0.35) | 5.78 (4.76–6.8) | <.0001 |
| 28-day hospital free days | ||||
| Unadjusted Model | 5.33 (0.13) | 19.31 (0.005) | −13.98 (−14.23–13.74) | <.0001 |
| Matched Subjects: Unadjusted Model | 5.52 (0.12) | 6.82 (0.14) | −1.3 (−1.56–1.04) | <.0001 |
| Matched Subjects: Model Adjusted using Unbalanced Covariates | 6.03 (0.1) | 7.41 (0.11) | −1.38 (−1.62–1.14) | <.0001 |
| 28-day ventilator free days | ||||
| Unadjusted Model | 13.79 (0.12) | 25.41 (0.004) | −11.62 (−11.85–11.38) | <.0001 |
| Matched Subjects: Unadjusted Model | 14.15 (0.17) | 16 (0.19) | −1.84 (−2.25–1.44) | <.0001 |
| Matched Subjects: Model Adjusted using Unbalanced Covariates | 15.67 (0.16) | 17.51 (0.18) | −1.84 (−2.24–1.44) | <.0001 |
| Total cost US $ | ||||
| Unadjusted Model | $355,219.61 ($1,734.28) | $79,230.97 ($61.82) | $275,988.63 ($272,587.34–$279,389.92) | <.0001 |
| Matched Subjects: Unadjusted Model | $347,369.67 ($5,815.62) | $285,286.87 ($4,970.28) | $62,082.81 ($48,549.53–$75,616.09) | <.0001 |
| Matched Subjects: Model Adjusted using Unbalanced Covariates | $313,507.68 ($4,852.56) | $256,287.96 ($4,470.02) | $57,219.72 ($44,626.05–$69,813.39) | <.0001 |
After propensity matching, ICU LOS and pre-ICU hospital LOS remained unbalanced covariates, which required further statistical adjustment to achieve balance between the groups. CI = Confidence interval; CIPNM = Critical illness polyneuromyopathy