Table IV.
Frequency of mutations in commonly deregulated head and neck cancer pathways
| Cell Cycle | RTK/RAS/PI(3)K | Cell Death | Differentiation | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
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| Gene | HPV − | HPV + | Gene | HPV − | HPV + | Gene | HPV − | HPV + | Gene | HPV − | HPV + |
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| Pathway | 96 | 100 | Pathway | 62 | 61 | Pathway | 44 | 31 | Pathway | 64 | 44 |
| CCND1 | 31 | 3 | EFGR | 15 | 6 | CASP8 | 11 | 3 | NOTCH | 26 | 17 |
| CDK6 | 8 | 0 | ERBB2 | 4 | 3 | TP53 | 84 | 3 | TP63 | 19 | 28 |
| CDKN2A | 57 | 0 | FGFR1 | 10 | 0 | FAT1 | 32 | 3 | |||
| RB1 | 4 | 6 | FGFR3 | 2 | 11 | ||||||
| E2F1 | 2 | 19 | IGF1R | 4 | 0 | ||||||
| MYC | 14 | 3 | HRAS | 5 | 0 | ||||||
| TP53 | 84 | 3 | PIK3CA | 34 | 56 | Activated Gene | |||||
| PTEN | 12 | 6 | Inactivation Gene | ||||||||