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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 Jul 24;234(19):2883–2895. doi: 10.1007/s00213-017-4684-8

Fig 2. Chronically-administered citalopram inhibits MDMA's effect on fear extinction 48 h later.

Fig 2

(a) Experimental model. (b) Conditioned freezing across groups of 4 CS re-exposures during extinction training (left) and testing (right) (n=10/group). (c) Average total conditioned freezing to CS during extinction training. Chronically administered citalopram blocked MDMA-induced reductions in conditioned freezing. (d) Average total conditioned freezing to CS during extinction testing. Chronically-administered citalopram significantly obstructed MDMA-induced reductions in conditioned freezing. (e) Experimental model. (f) Average total conditioned freezing during extinction testing. Acute citalopram treatment 24 h prior to extinction training did not alter MDMA‟s lasting effect on conditioned freezing during extinction testing (n=8/group). *p < 0.05; # p < 0.001