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. Author manuscript; available in PMC: 2018 Oct 1.
Published in final edited form as: Psychopharmacology (Berl). 2017 Jul 24;234(19):2883–2895. doi: 10.1007/s00213-017-4684-8

Fig 4. MDMA's effects on extinction of fear-potentiated startle (FPS).

Fig 4

(a) Experimental model. MDMA was administered 20 min prior to extinction training. (b) Average FPS across sets of 4 CS re-exposures during memory testing (Pre), extinction training (Day 7), and extinction testing (Day 8). 7.8 mg/kg treatment resulted in significantly less FPS during CS trials 1,2, 5 and 10 compared to vehicle treatment (n=16/group). (c) Total FPS in response to CS re-exposure during extinction training when MDMA was administered 20 min prior to extinction training. All treatment groups had significantly less FPS than the control vehicle-treated group (n=16/group). (d) Total FPS in response to CS re-exposure during extinction testing. Only 7.8 mg/kg treatment resulted in significantly less FPS than the vehicle-treated group (n=16/group). *p < 0.05; ^p < 0.01; #p < 0.001.