Table 3.
Association of long-term changes in weight or BMI with overall and CRC-specific survival, modeled continuously or categorically.
| Overall mortality | CRC-specific mortality | |||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
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| n(deaths) | HR*† | 95% CI | p-value | n(deaths) | HR* | 95% CI | p-value | |
| Per 5kg loss | 2049(344) | 1.13 | 1.07–1.21 | <0.001 | 2049(91) | 1.25 | 1.13–1.39 | <0.001 |
| Per 1kg/m2 loss | 2049(344) | 1.07 | 1.03–1.11 | <0.001 | 2049(91) | 1.13 | 1.06–1.20 | <0.001 |
| Gain >5% | 678(88) | 1.01 | 0.76–1.35 | 0.95 | 678(20) | 0.9 | 0.51–1.60 | 0.73 |
| Same (+/-5%) | 985(139) | Ref. | 985(31) | Ref. | ||||
| Loss >5% | 386(117) | 2.58 | 1.97–3.38 | <0.001 | 386(40) | 4.31 | 2.63–7.06 | <0.001 |
| Gain >2kg | 821(114) | 1.11 | 0.83–1.48 | 0.50 | 821(27) | 1.22 | 0.67–2.24 | 0.52 |
| Same (+/-2kg) | 711(92) | Ref. | 711(18) | Ref. | ||||
| Loss >2kg | 517(138) | 2.03 | 1.52–2.70 | <0.001 | 517(46) | 4.22 | 2.38–7.49 | <0.001 |
*
Adjusted for age at diagnosis, sex, smoking history, NSAID use, stage at diagnosis, time from diagnosis to baseline survey, baseline BMI category, and study.
†
Stratified by age at diagnosis (proportional hazards violation).