Table 4.
Association of long-term BMI category change with long-term overall and CRC-specific survival.
| Overall mortality | CRC-specific mortality | |||||||
|---|---|---|---|---|---|---|---|---|
|
|
|
|||||||
| n(deaths) | HR* | 95% CI | p-value | n(deaths) | HR* | 95% CI | p-value | |
| Normal to Obese | 15(4) | † | 15(1) | † | ||||
| Normal to Overweight | 169(15) | 0.84 | 0.47–1.53 | 0.58 | 169(6) | 0.84 | 0.31–2.26 | 0.73 |
| Maintained Normal | 514(75) | Ref. | 514(19) | Ref. | ||||
| Normal to Underweight | 15(5) | 2.23 | 0.87–5.71 | 0.09 | 15(2) | † | ||
| Overweight to Obese | 147(16) | 0.88 | 0.50–1.55 | 0.65 | 147(2) | † | ||
| Maintained Overweight | 531(76) | Ref. | 531(17) | Ref. | ||||
| Overweight to Normal | 110(41) | 3.67 | 2.41–5.60 | < 0.001 | 110(15) | 6.68 | 3.06–14.55 | <0.001 |
| Overweight to Underweight | 3(0) | † | 3(0) | † | ||||
| Maintained Obese | 422(75) | Ref. | 422(18) | Ref. | ||||
| Obese to Overweight | 84(22) | 1.69 | 1.00–2.85 | 0.049 | 84(6) | 1.86 | 0.67–5.18 | 0.24 |
| Obese to Normal | 9(3) | † | 9(2) | † | ||||
| Obese to Underweight | 1(0) | † | 1(0) | † | ||||
*
Adjusted for age at diagnosis, sex, smoking history, NSAID use, stage at diagnosis, time from diagnosis to baseline survey, baseline BMI, and study.
†
Estimate not reported due to <5 events.