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. Author manuscript; available in PMC: 2017 Dec 21.
Published in final edited form as: Mucosal Immunol. 2017 May 17;11(1):209–219. doi: 10.1038/mi.2017.41

Figure 7.

Figure 7

IL-5 neutralization suppresses the eosinophil response and abrogates resistance of BALB/c IFN-γ −/− mice to CA04 infection. (a) Schematic timeline showing CA04 infection, treatment with α-IL-5 mAb or IgG isotype control, and BALF harvesting for immunological analyses. (b) CA04-infected mice were treated with α-IL-5 mAb or IgG isotype control, and monitored for survival. Data shown were pooled from four independent experiments. (c,d) Total numbers of IL-5+ILC2s (c) and eosinophils (d) in the BALF 9 days after CA04 virus infection of mice treated with α-IL-5 mAb or IgG isotype control. (e–g) Levels of IL-5 (e), amphiregulin (f) and IL-13 (g) in the BALF 9 days after CA04 virus infection of mice treated with α-IL-5 mAb or IgG isotype control. (h–k) Viral burden (h), nitrite levels (i), total protein (j), and albumin levels (k) in the BALF 9 days after CA04 virus infection of mice treated with α-IL-5 mAb or IgG isotype control. (b) Survival data were analyzed with log-rank Mantel-cox test. ** P<0.01. (c–k) Statistical analyses were performed by two-way ANOVA. ** P<0.01; *** P<0.001; **** P<0.0001. Data pooled from two independent experiments.