Table 1.

Genes identified from analysis of rare variant counts in combined Chinese and European ancestry data

Gene	Model	European p valuea	Chinese p valueb (Case/control)c	Combined p valued	Combined OR (low/high)
NEK1	Dom coding	4.7 × 10–6	6.7 × 10–3 (11/2)	6.6 × 10–7	2.3 (1.6/3.2)
	Dom not benign	2.2 × 10–6	5.0 × 10–2 (7/0)	3.1 × 10–7	2.9 (1.9/4.4)
	Dom LoF	3.2 × 10–9	3.8 × 10–1 (2/0)	1.1 × 10–9	8.2 (3.7/20.7)
SOD1	Dom coding	7.1 × 10–8	3.7 × 10–2 (9/1)	8.9 × 10–9	9.5 (3.8/28.4)
	Dom not benign	3.9 × 10–7	5.3 × 10–2 (8/1)	6.9 × 10–8	11.7 (3.9/47.5)
	Dom LoF	NA	NA	NA	NA
TBK1	Dom coding	1.3 × 10–9	1.4 × 10–1 (7/1)	2.3 × 10–10	3.8 (2.4/5.9)
	Dom not benign	3.6 × 10–11	1.9 × 10–1 (6/1)	8.3 × 10–12	5.9 (3.3/10.8)
	Dom LoF	1.6 × 10–6	2.5 × 10–1 (1/0)	9.6 × 10–7	13.1 (3.7/70.9)

^aCochran–Mantel–Haenszel test (Cirulli et al., 2015) [9]

^bSKAT-O test [29]

^cNumber of Chinese case carriers and control carriers out of 610 cases and 460 controls

^dCochran–Mantel–Haenszel test