Skip to main content
. 2001 Aug 21;98(18):10196–10201. doi: 10.1073/pnas.171325898

Figure 3.

Figure 3

Orthologs of zebrafish cldna and cldnb are expressed in vertebrate primordia. (a) Conserved syntenies between zebrafish linkage groups 15 and 21, which harbor paralogous clusters of claudin genes that include cldna and cldnb, and human chromosome 7, which contains CLDN3 and CLDN4. We mapped putative zebrafish orthologs of six genes from the vicinity of CLDN3 and CLDN4 (45); two of them, hip1 and wbscr1, occur in LG15 near cldna (Table 2). In addition, zebrafish LG21 harbors the ortholog of the human CCT6A gene on 7p11 (46). (b) In situ hybridization of a stage 30 X. laevis embryo with an antisense probe for frog cldna. (c–e) In situ hybridizations of mouse embryos between embryonic days 9.0 and 9.5 with antisense probes for Cldn3, Cldn4, and Cldn6. All views are lateral. BA, branchial arches; OV, otic vesicle; PD, pronephric duct; TB, tail bud; Olf, olfactory placode; FB, forelimb bud.