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Criteria used to establish keratoconus progression in cross-linking clinical trials [21]
| Steepest keratometry (K max) | >1 D increase from baseline |
| Flattest keratometry (K min) | >1 D increase from baseline |
| Mean keratometry (K mean) | >0.75 D Increase from baseline |
| Corneal apex power | >1 D increase from baseline |
| Manifest spherical equivalent | >0.5 D difference from baseline |
| Central corneal thickness | >2% decrease from baseline |
D diopter
